College Honors Faculty Members With 2015 Teaching Awards
Janna Shedd, Tonya Bates and Robin James have received the College of Liberal Arts and Sciences’ 2015 Teaching Awards for their dedication, teaching and research contributions and lasting impact on students.
Shedd of Religious Studies won the College’s Award for Outstanding Teaching by a Part-Time Faculty Member. Bates of Biological Sciences won the College’s Award for Outstanding Teaching by a Full-Time Lecturer. James of Philosophy won the College’s Integration of Undergraduate Teaching and Research Award.
They received their awards at a ceremony on Monday, April 20. Also at the ceremony, the finalists for each award were honored.
The two finalists for the Outstanding Teaching by a Part-Time Faculty Member Award are Allison Hutchcraft of English and Lawrence Blydenburgh of Criminal Justice and Criminology.
The two finalists for the Outstanding Teaching by a Full-Time Lecturer Award are John Taylor of Mathematics and Statistics and Sue Hodge of Criminal Justice and Criminology.
The two finalists for the Integration of Undergraduate Teaching and Research Award are Joe Kuhns of Criminal Justice and Criminology and Paula Connolly of English.
“These faculty members help students understand that taking risks is part of intellectual and emotional growth,” said Dean Nancy A. Gutierrez. “They help students understand that their capacity for success is constrained only by obstacles of their own invention. This is the power of a liberal arts education.”
Janna Shedd: Award for Outstanding Teaching by a Part-Time Faculty Member
Shedd is a part-time lecturer in the Religious Studies Department of the University of North Carolina Charlotte, where she has taught since 2009. Janna completed her master’s degree at UNC Charlotte and her bachelor’s degree at UNC Asheville. Her research interests are South and East Asian religions, the effects of globalization on religion and culture, and multicultural education. For the last 18 months she has volunteered at a weekly community and educational outreach program for local Southeast Asian youth.
She has traveled to China for month-long excursions to religious sites across the country and was adopted by a monkey on her last trip three years ago. Shedd hopes to expand her travel destinations and the frequency of her trips in the future. Her goals for the next two years include publishing articles on teaching religion, leading a student tour group to Daoist sites in China, and expanding her scholarly expertise to include Japanese religions.
She earned her master’s degree in religious studies from UNC Charlotte in 2009 and has been a part-time lecturer with a 4-4 load since fall semester of that year. With her tremendous sense of initiative and imagination, she has developed courses, including an online version of Death and the Afterlife.
Students describe her as engaging, passionate and patient. They express appreciation for the way she shows them other ways of life that differ from their own, and how their respect for other cultures and choices grows through her example. She shows this respect in the classroom.
One student commented, “Professor Shedd was possibly one of the most impressive, intelligent and compelling professors I have had the good fortune of enjoying in five semesters. She was able to get even the most timid and quiet student engaged. Neither obscure nor fatuous questions seemed to slow her down, and if ever she did not know an answer, she always found it out for us.”
To explain her motivation for teaching, Shedd said, “By the time they leave my class at the end of the semester, I hope that each student feels more confident in their ability to take on the world and all it has to offer. In the end, I am really trying to teach students how to teach themselves, to value each other, and to see their own education as relevant, active, and ongoing.”
Tonya Bates: Award for Outstanding Teaching by a Full-Time Lecturer
A native North Carolinian, Bates earned a master’s degree in biology and as a graduate student taught introductory biology and microbiology labs at UNC Charlotte. After graduation, she worked as a researcher in industry, at UMASS Amherst, and at Carolinas Medical Center, which provided her with a broad range of clinical and technical skills. Along this journey, she discovered that more than doing bench research, she enjoyed sharing biology through teaching and mentoring.
Bates is currently a lecturer in the Department of Biological Sciences and recently took on the role of undergraduate coordinator. She teaches majors and non-science majors in a variety of courses including Principles of Biology, Nature of Science and Current Topics, and Public Health for educators. The undergraduate coordinator position enables her to have an impact on the undergraduate curriculum of biology majors in a way that is not possible as an instructor.
By participating in the Communication across the Curriculum program, she has initiated improving writing in her department by facilitating the use of peer writing mentors in select writing intensive courses.
Recently she was selected to participate in the Top 40 faculty academy to write a resource guide for new faculty in these large enrollment freshman courses. In her spare time, she promotes science in the community by participating in events such as the UNC Charlotte Science and Technology Expo and Science Olympiad. With colleagues, she continues to develop many professional development workshops for middle, high school, and AP biology teachers.
Bates’ other scientific achievements and involvement include participation in the SouthEast Summer Institute for Undergraduate Education in Biology in 2012, the position of liaison for the Center for Teaching and Learning, election to the Department Advisory Committee, and representing for the Women in Science program at UNC Charlotte.
One student nominator said this: “She is able to make small group projects work in a large class of 200 students, which seems like a magic trick to me.” Another student nominator said, “Professor Bates constantly gives creative analogies and finds ways to link what we are learning in class to our own lives. She is truly a phenomenal professor.” On of these creative endeavors includes “DNA Theater,” during which Bates and her students “dynamically act out the processes of DNA transcription and translation.”
Bates said, “Since 2010, I’ve taught biology to approximately 3,000 students. Each of these students has provided an opportunity to re-examine and reflect on why I do things the way I do inside and outside the classroom…. My personal goal has been to use my background as a scientist as an opportunity to do research to improve, develop, and refine my teaching and ultimately be able to communicate and disseminate this knowledge.”
Robin James: Integration of Undergraduate Teaching and Research Award
James is an associate professor of Philosophy at UNC Charlotte. She is the author of two books: Resilience & Melancholy: pop music, feminism, and neoliberalism, which was published by Zero books in February 2015, and The Conjectural Body: gender, race and the philosophy of music, which was published by Lexington Books in 2010.
Her work on feminism, race, contemporary continental philosophy, pop music, and sound studies has appeared in The New Inquiry, Noisey, SoundingOut!, Hypatia, differences, Contemporary Aesthetics, and the Journal of Popular Music Studies. She is also a digital sound artist and musician, and often works as a member of citation:obsolete. She blogs at its-her-factory.com and is a regular contributor to Cyborgology and xcphilosophy.
For James, the integration of teaching and research means using classroom conversations as a place to begin and continue her own research practice and teaching students some of the practices, including blogging, public writing, creative research in sound and the process of writing a book. “Often the questions I bring to class are ones I’m still working on, to which I don’t yet have answers,” James said. “The classroom is a place where the students and I work through philosophical questions, concepts, and problems together.”
Shannon Sullivan, Chair and Professor of Philosophy, said, “[I]t is not so much her scores that make Dr. James truly deserving of this award. It is what she does in her classes. Dr. James and her students do philosophy together.”
“As I understand it, philosophy is not so much a content […] but more of a how, a doing, a practice. So in all my classes, we do philosophy, we think,” James said.
James plans to integrate students’ thinking with media and philosophy. She has developed a new team-taught course for spring 2016, supported by an SOTL grant, that will give students the opportunity to engage philosophy via new media including film, video, websites and social media. They will interview Charlotte people on topics that connect philosophy to their lives. This will continue her practice of giving students hands-on experience developing philosophical ideas in ways that model what scholars do.
Students commend James for being, as one student described it, “a valuable living resource.” The student commented, “She encourages us, and in doing so helps us to realize the potential works that lie within us. But what distinguishes her from other professors I have is not just her ability to understand her students, but her affinity for understanding her students.”
Words compiled and edited by Taryn Walls, Student Communications Assistant
Images: Lynn Roberson, College Communications Director.
Pictured in top photo (left to right): Tonya Bates, Janna Shedd, Robin James, Nancy Gutierrez
Tonya Bates Honored as Teaching Award Finalist
Tonya Bates of Biological Sciences is one of three nominees for the College of Liberal Arts & Sciences Award for Outstanding Teaching by a Full-Time Lecturer. The other nominees are John Taylor of Mathematics and Statistics and Sue Hodge of Criminal Justice and Criminology.
A native North Carolinian, Bates earned a master’s degree in biology and as a graduate student taught introductory biology and microbiology labs at UNC Charlotte. After graduation, she worked as a researcher in industry, at UMASS Amherst, and at Carolinas Medical Center, which provided her with a broad range of clinical and technical skills. Along this journey, she discovered that more than doing bench research, she enjoyed sharing biology through teaching and mentoring.
Bates is currently a lecturer in the Department of Biological Sciences and recently took on the role of undergraduate coordinator. She teaches majors and non-science majors in a variety of courses including Principles of Biology, Nature of Science and Current Topics as well as Public Health for educators. The undergraduate coordinator position enables her to have an impact on the undergraduate curriculum of biology majors in a way that is not possible as an instructor.
By participating in the Communication across the Curriculum program, she has initiated improving writing in her department by facilitating the use of peer writing mentors in select writing intensive courses.
Recently she was selected to participate in the Top 40 faculty academy to write a resource guide for new faculty in these large enrollment freshman courses. In her spare time, she promotes science in the community by participating in events such as the UNC Charlotte Science and Technology Expo and Science Olympiad. With colleagues, she continues to develop many professional development workshops for middle, high school, and AP biology teachers.
She describes her teaching philosophy as “student-centered” and she strives to use a range of engagement strategies including low-stakes formative assessment, hand-on activities, and small group exercises. Her goal is to make students scientifically literate. One student nominator said this: “She is able to make small group projects work in a large class of 200 students, which seems like a magic trick to me.” Another student nominator said that “Professor Bates constantly gives creative analogies and finds ways to link what we are learning in class to our own lives. She is truly a phenomenal professor.”
John Taylor Honored as Teaching Award Finalist
John Taylor of Mathematics and Statistics is one of three nominees for the College of Liberal Arts & Sciences Award for Outstanding Teaching by a Full-Time Lecturer. The other nominees are Tonya Bates of Biological Sciences and Sue Hodge of Criminal Justice and Criminology.
Taylor attended both public and Catholic schools and graduated from Rocky Mount Senior High School where he played saxophone in the school’s national award winning marching band. He went on to attend N.C. State University where he graduated with his bachelor’s degrees in mathematics and military history. Continuing on at N.C. State, he graduated with a master’s degree in applied mathematics. During his graduate studies Taylor received an award for Outstanding Graduate Student Teaching, the first of many awards
After graduating, Taylor accepted a positon as a professor of mathematics at Nash Community College as well as working as an adjunct professor at NC State and Peace College in Raleigh. During his time at Nash Community College, Taylor became known among students and faculty as the “Math Guy” and his excellence in teaching was again recognized by being awarded the Teacher of Year. Ever since graduating with his undergraduate degree, he also worked part-time at the North Carolina State Archives as a Military historian and accompanied lecture tours for history and genealogy.
He eventually came to UNC Charlotte to complete his doctoral degree in Mathematics. As a graduate student, Taylor continued teaching and very quickly gained popularity among students for his unique and effective teaching style and won the Graduate Teacher of the Year award.
In 2006 he graduated with his Ph.D. in Commutative Ring Theory, and was immediately offered a position at UNC Charlotte. Taylor still works for UNC Charlotte, and is an in-demand faculty member in the Mathematics and Statistics Department.
He believes that “teaching is a complex art and effective teaching involves a multitude of variables. My mission as a teacher is to carefully consider all these elements and to provide a teaching-learning environment which is conducive to each student’s learning.” Students agree that he is successful in achieving this mission. One student nominator said this: “Dr. Taylor helped me so much. His voice is still in my head, in a good way I mean. He engraved Calculus I and II in my head. So in my major classes I’m finding it very easy to use calculus-related equations while I see others struggle.”
Dr. Pinku Mukherjee Wins O. Max Gardner Award 2015
Distinguished cancer researcher Pinku Mukherjee was honored with the O. Max Gardner Award – the highest faculty accolade given by the Board of Governors of the University of North Carolina.
The award, established by a provision in the will of Gov. O. Max Gardner, recognizes UNC system faculty members who have “made the greatest contribution to the welfare of the human race.” It is the only award for which all faculty members on the 17 UNC campuses are eligible. The honor, given annually since 1949, carries a $20,000 cash prize.
Mukherjee Honored With Board of Governors’ Highest Faculty Accolade
Distinguished cancer researcher Pinku Mukherjee was honored with the O. Max Gardner Award – the highest faculty accolade given by the Board of Governors of the University of North Carolina. She was presented the honor formally Friday, April 10.
The award, established by a provision in the will of Gov. O. Max Gardner, recognizes UNC system faculty members who have “made the greatest contribution to the welfare of the human race.” It is the only award for which all faculty members on the 17 UNC campuses are eligible. The honor, given annually since 1949, carries a $20,000 cash prize.
As the Irwin Belk Endowed Professor of Cancer Research at UNC Charlotte, Mukherjee is transforming the ways in which cancer is diagnosed and treated. She has designed innovative approaches to more accurately detect breast cancer early and is developing targeted therapy and imaging for pancreatic, ovarian and colon cancers. Her appointment is in the Department of Biological Sciences in the College of Liberal Arts & Sciences.
To date, Mukherjee has published 65-plus peer-reviewed journal articles that have been cited or referenced more than 11,000 times. Her groundbreaking cancer research has produced one U.S. patent and has resulted in grants from the National Institutes of Health, the U.S. Department of Defense, and the Susan G. Komen Foundation totaling more than $3.5 million as principal investigator and more than $500,000 as co-investigator.
Mukherjee also is an astute entrepreneur. Using an innovative approach to cancer research as a basis, she and her team founded the biotechnology company OncoTab Inc. in 2011 (previously CanDiag Inc.). A UNC Charlotte spinoff, OncoTab Inc. develops and commercializes products that span the lifecycle of cancer, from initial diagnosis through treatment and recurrence monitoring. The company has an exclusive license to a patented technology platform that has successfully demonstrated diagnostic, imaging, and therapeutic capabilities with breast, prostate, and pancreatic cancers. The company already has won several awards including one from NCBiotech as well as the grand prize at the Charlotte Venture Challenge.
Prior to joining UNC Charlotte in 2008, Mukherjee was with the Mayo Clinic. She received her bachelor’s degree in microbiology from Bombay University, India, and her master’s and doctoral degrees from the University of London.
Behnam Pourdeyhimi, the Klopman Distinguished Professor of Textile Materials at North Carolina State University, also was named an O. Max Gardner Award recipient for 2015.
Traditionally only one winner of the award is named per year, but committee members were equally impressed with the work of Mukherjee and Pourdeyhimi, said Gardner Award Committee Chair Ann Maxwell. In addition to being world-class scientists and leaders in their fields, she said, the two are “outstanding teachers, unique mentors and tireless ambassadors for our state and our universities.”
Pictured: Mukherjee in her lab with members of her team.
UNC Charlotte Hosts Science, Technology Events
The 2015 North Carolina Science Festival, a statewide celebration of science and technology, is again offering cool things for the public to experience from April 10-26. UNC Charlotte is ramping up its participation as part of the festival’s seasonal offerings. In addition to its traditional Science and Technology Expo (now in its fourth year), the University will offer a science activity series, science and society panel series, two award-winning science documentary films and a star party.
The always-popular Science and Technology Expo will remain the University’s grand finale, closing out the festival. It will be from noon to 4 p.m., Sunday, April 26, with activities including robotics, rocketry, virtual people, live animals, lab experiments, explosive chemistry, exotic plants, fire engines, race cars, boats and drones. The event is for the science-curious of all ages, featuring 100-plus hands-on activities and presentations in chemistry, physics, geology, computer science, engineering and biology developed by University personnel and a host of industry and community organizations.
REGISTRATION CLOSED: The UNC Charlotte Observatory’s night of expertly-guided star-gazing, during its second annual N.C. Science Festival Star Party at 8 p.m., Friday, April 24 is sold-out.
As the festival opens on Friday, April 10, the UNC Charlotte College of Arts + Architecture and UNC Charlotte’s Urban Institute invite the public to the Projective Eye Gallery, located in UNC Charlotte Center City, to explore an environmental issue going on in their own neighborhoods and backyards as the gallery’s ongoing “Keeping Watch” initiative presents “City of Creeks.” Works by artists Lauren Rosenthal, Stacy Levy, Marek Ranis, and Nancy Pierce explore Charlotte waterways in diverse media and from a range of perspectives – geographic, scientific, aesthetic and spiritual. A host of College of Liberal Arts & Sciences students, faculty and alumni also have provided research for the effort. The exhibition runs through June 17.
On Saturday, April 11, UNC Charlotte’s Graduate School will host the University’s annual Graduate Research Symposium: explore the world of University research, as seen through the work of graduate researchers – scholars and scientists at the beginning of their professional careers in expanding human
understanding. The day-long symposium (Atkins Library, 9 a.m. to 4 p.m.) features poster sessions where the researcher explains the work he or she has conducted, as well as a program of research presentations.
On Friday, April 17, the College of Computing and Informatics will present “Inside the Design Studio,” an interactive design studio tour from 8 to 11 a.m., in Woodward Hall, Room 308. Touring one of the University’s most innovative learning and research labs, visitors will learn about the innovative ideas generated by students designing new interactive systems for the kitchen. Each semester, the Interaction Design Studio develops and integrates novel technologies in gesture, speech and tangible interaction to design new ways of interacting with the environment. This semester, the studio is working with the design innovation manager at Electrolux to focus on a better collaboration between people and appliances for interactive food preparation, intelligent food storage and minimizing food wastage. Visitors will be invited to explore the lab and critique student efforts. Advance registration is required.
With a nod to the N.C. Science Festival’s 2015 theme of “science and music,” UNC Charlotte is capping off its list of interactive events with a free concert, “Tape, Loop, Delay: Science, Technology and Contemporary Percussion Music.” In this event, percussionist Scott Christian will explore the science of sound and the role of new technologies in contemporary concert music, with a performance-demonstration that features music for percussion and live and recorded electronics. The concert, which is free and open to the public, is scheduled for 12:30 p.m., Friday, April 24 in PORTAL Building, Room 102.
Continuing with the goal of making festival offerings engaging, event planners have modified the University’s traditional faculty lecture series into “Science and Society Panel Discussions,” featuring talks on controversial (and sometimes confusing) science and technology issues, led by noted researchers in the field. All events in the series are free and open to the public.
The first event in this series is at 7 p.m., Monday, April 13, in EPIC Building, Room G256, and is entitled “Humans and Technology: Conflict or Convergence? UNC Charlotte and the Watson Story.” Following the example of IBM’s “AI” Watson, the p
anel will explore data science possibilities and potential problems to help the audience understand the promises and challenges of a field of research that is literally working to mold the technological future of humanity. The panel will feature UNC Charlotte data analytics researchers Mirsad Hadzikadic, Wlodek Zadrozny (a researcher in the Watson Project) and Diane Fodell.
“Controversies and Concerns: Agricultural Biotechnology and GMOs” is a panel discussion on the publicly contentious (and often poorly understood) issue of genetically modified organisms and their use in food, medicine and in the environment. This event will be led by two prominent biotechnology researchers, UNC Charlotte biologists Kenneth Bost and Kenneth Piller. They will lead a conversation about GMOs current use in medicine and agriculture, their future potential and public fears. The panel is scheduled for 7 p.m., Wednesday, April 15, in the Bioinformatics Building, Room 105.
Concluding the series, in a discussion that is sure to be of interest to teachers, administrators, coaches and every parent of a school athlete, will be “Controversy and Concerns: Concussions in Sports.” This panel-led presentation and discussion will examine the risks of concussion injuries in sports, the science of brain trauma and the social issues involved. The expert panel features College of Health and Human Services researchers Erik Wikstrom, Tricia Turner and Bret Wood. The event is scheduled for 7 p.m., Tuesday, April 21, in the Bioinformatics Building, Room 105.
The University’s Science Film Series will focus on award-winning documentaries about science in the news.
The two-film mini-festival opens with a screening of “Shored Up” at 7 p.m., Monday, April 20, in the Student Union Movie Theater. The film is a documentary about climate change and sea level rise – an issue of some concern in North Carolina. According to the producers, “’Shored Up’ is a documentary that asks tough questions about our coastal communities and the relationship to the land. What will a rising sea do to our homes, our businesses, and the survival of our communities? Can we afford to pile enough sand on our shores to keep the ocean at bay? In Long Beach Island, New Jersey and the Outer Banks of North Carolina, surfers, politicians, scientists and residents are racing to answer these questions.” A panel discussion featuring environmental science and earth science researchers Scott Hippensteel, UNC Charlotte; Alex Glass, Duke University; and Andrew Coburn, Program for the Study of Developed Shorelines, Western Carolina University, will follow.
The film series concludes with a documentary about the biggest news in physics for years: “Particle Fever” at 7 p.m., Wednesday, April 22, in the Student Union Movie Theater. A documentary about the hunt for the Higgs Boson, “Particle Fever” is both about science at its geekiest and most romantic.
All events are sponsored by UNC Charlotte in association with the N.C. Science Festival. University sponsors include UNC Charlotte Research and Economic Development. Charlotte-Mecklenburg Schools is a community partner, and WCNC TV is the media partner. Support has been provided by the University of North Carolina General Administration through a grant administered by the N.C. Science Festival.
Words: Jim Hathaway
Images from 2014 events: Lynn Roberson
Little Sugar Creek image: Nancy Pierce
Levine Scholar, Biology Major Named Newman Civic Fellow
Junior biology major Sarah Whitmire has been named a Campus Compact Newman Civic Fellow, one of 201 students honored with this national award for investing in their communities through service, research and advocacy.
A Levine Scholar, Whitmire is minoring in music and public health sciences. She is pursuing her medical education, engaging in health research and volunteering in related organizations, all to prepare her serve vulnerable populations in ways that improve the quality of their lives.
“While the reasons for volunteering might be different from person to person, I’ve always felt a strong drive to use my skills to improve the lives of those with the fewest resources,” she said. “Volunteering has solidified my reasons for choosing this path, which will provide a means for me to make a lasting impact in any community.” Whitmire’s ultimate plan is to become a physician.
She has conducted research on campus and in the community, including at Carolinas Healthcare System. She began volunteering three years ago with the non-profit clinic affiliated with the Salvation Army Homeless Shelter, which serves women and children in the Charlotte-Mecklenburg area. The clinic promotes self-sufficiency by providing free healthcare.
“In addition to working directly with the residents, I’ve participated and initiated multiple health-related projects at the shelter to promote health, to provide education, and to encourage preventative measures,” she said. “One of my most significant accomplishments was creating a research project with the goal of providing a self-sustainable way for this high-risk population to control their blood pressure. Throughout the 500 plus hours of working there, I’ve developed leadership and civic engagement skills that will be applicable for the rest of my life, in addition to developing many unique friendships.”
Whitmore has always been driven to understand the intersection between the patient, the protocol, and the system, UNC Charlotte Chancellor Philip L. Dubois said. “The two-year relationship she has developed with homeless women in her community-based research project in Charlotte has equipped her to make a difference in the lives of the people for whom she cares, and to witness firsthand the challenges people face in accessing health education and services,” Dubois said. “Ms. Whitmire’s understanding of the patient at a human level positions her to take this integrated perspective into her graduate student and professional life, as she continues to explore the multiple facets of health interventions and service delivery.”
Named in honor of Frank Newman, one of the founders of Campus Compact, the Newman Civic Fellow award is sponsored by the KPMG Foundation. Newman Civic Fellows share as a collaborative group their ideas and other information to further their work.
Campus Compact is a national coalition of more than 1,100 college and university presidents who are committed to fulfilling the public purpose of higher education. As the only national higher education association dedicated solely to campus-based civic engagement, Campus Compact promotes public and community service that develops students’ citizenship skills, helps campuses forge effective community partnerships, and provides resources and training for faculty seeking to integrate civic and community-based learning into the curriculum.
Unraveling Cystic Fibrosis Puzzle, Researchers Draw From the Personal
In the genetic disorder cystic fibrosis, the most severe symptoms are recurring episodes of lung inflammation and bacterial infection (known as “exacerbations”) that happen from one to three times a year and cause ever-increasing amounts of lung damage through the course of a CF patient’s life. While it is well understood that CF lung problems are ultimately due to bacterial infections encouraged by a CF patient’s abnormally thick mucus, medical science has been unable to define specific causes that trigger the periodic flare-ups.
In a recent article in the Journal of Clinical Microbiology, lead author Joshua Stokell – a post-doctoral researcher in biology – and a team from the University of North Carolina at Charlotte describe an unusual, single-patient study and an important finding that may point to an immediate cause of CF exacerbations.
The study found sudden growth of a specific bacterium, Burkholderia multivorans, preceded periods of acute illness. While B. multivorans has been known as a common pathogen in the lungs of CF patients, it is far less abundant than another pathogen, Pseudomonas aeruginosa, whose populations did not show significant changes prior to the life-threatening episodes.
Stokell’s co-authors on the paper are UNC Charlotte biologist Todd Steck and UNC Charlotte bioinformaticians Anthony Fodor, Malcolm Zapata, Raad Gharaibeh and Timothy Hamp.
Stokell and his colleagues were able to implicate B. multivorans thanks to a detailed genomic and metagenomic analysis of a unique, extensive collection of lung sputum samples taken twice-weekly over a three-year period.
“This study represents the most intensive sampling of a single CF patient to date,” the article notes. “Our study was based upon the assumption that a detectable shift in the bacterial community precedes a pulmonary exacerbation. Testing our assumption required a longitudinal study to reveal the relationship between disease progression, occurrence of a pulmonary exacerbation and various components of a bacterial community, such as the change in diversity, richness, or the abundance of specific members of the microbiota.”
“Most studies that you look at collect one pre-exacerbation sample, one during exacerbation and one during periods of stability,” Stokell noted. “With that kind of study, it’s hard to get an idea of how changes are occurring because those are more like cross-sectional analyses. Our focus was to look at how these changes are occurring generally, and in order to get some sort of baseline information we have to check changes frequently over time.”
Stokell Draws From Personal Insights
In discussing the work, Stokell is somewhat shy about mentioning that the unusually extensive sampling and analysis was only possible because of the willing contribution of an unusually cooperative patient: himself.
Because Stokell was both the researcher and the study subject, the team gained unparalleled access to the subject’s life history and medical records, providing critical context. “We have all kinds of patient background information,” Stokell noted, “so we can associate the changes in bacteria with the occurrence of an exacerbation and also with when antibiotics are administered.”
Chronic diseases like CF are often daunting puzzles that require an extraordinary amount of research effort to understand — the long-term interaction between the human body’s dynamic systems and the disease can be extremely complex, even when there’s a relatively simple initiating cause, such as a genetic defect. Consequently, researchers studying such diseases need an extra amount of commitment and passion to struggle with the intricate complexities involved.
In Stokell’s case, the commitment and passion came naturally because the disease is personal. Steck, whose lab Stokell now works in, was Stokell’s mentor in college and in graduate school. Steck observed that the experience of having cystic fibrosis played an important role in developing Stokell’s initial general interest in biology and in leading him to the line of research that he is now pursuing.
Stokell Begins Research As UNC Charlotte Student
As a master’s student at UNC Charlotte, Stokell took a class in bioinformatics from Anthony Fodor, where students had to come up with projects involving metagenomic analysis of bacterial populations. Stokell recognized that this might be an important research area relevant to his own disease, so he chose lung bacteria in cystic fibrosis, with himself as a research subject. Once engaged, he found that the interaction between CF and the human microbiome is difficult to unravel, but his personal connection to the disease kept him motivated.
The current study still does not answer all the questions raised by Stokell’s class project, though he has now done both metagenomic analysis (which allows cataloging the full range of bacterial populations by finding variants of the 16S rRNA gene) and whole-genome sequencing (on a small group of bacterial varieties) on three year’s worth of steady sampling.
In addition to identifying Burkholderia as a key pathogen, the team found that richness and diversity of bacterial communities decreased over time, while the overall abundance of bacteria increased, perhaps due to ongoing antibiotic treatment and the steady progress of the disease. However, those changes are not associated with the disease’s damaging flare-ups.
“There were no changes in the metagenomic sequencing and the relative abundance of bacterial communities that were specifically associated with the occurrence of exacerbation,” Stokell said.
“Nothing that occurred within two weeks prior to the exacerbation indicated this is what is causing the individual to become ill,” he said. “We did see treatment effects for richness and diversity — we saw those decreases during antibiotic treatment. And over a three-year period, bacteria continued to increase in abundance. But when we looked at specific pathogens, Burkholderia was the one that showed an increase in abundance prior to exacerbation. So we can speculate that that was the initiator of the exacerbation.”
The next step, the researchers say, is to do further study on a larger group of patients. Stokell and Steck have received grants from NIH and the Cystic Fibrosis Foundation that will allow them to do that. If findings in a larger sample support the pattern Stokell has found in himself, treatment of Burkholderia specifically may be an important target in managing the damaging effects of the disease.
Challenges Lie Ahead for Stokell
Though significant research problems undoubtedly lie ahead, the real challenge for Stokell perhaps is the personal one he faces in the progress of his own disease. Though he has struggled all his life to maintain his health, at age 35 Stokell is now in late stage lung disease and will need a lung transplant sometime in the near future.
“I’m being considered for a double-lung transplant at Duke University Medical Center,” Stokell said, explaining that this entails not just a complex operation but also three months of pre-operation preparation and six months of recovery on-site, not to mention expensive medications he will be required to take for the rest of his life. The difficulty of his situation is not limited to surviving until the transplant and enduring the medical realities.
“Undergoing a transplant is not only difficult because of the surgery; the associated monetary costs are quite high,” he said. “Typically, individuals in my situation are required to raise money prior to the surgery.”
To raise the funds for transplant-related expenses, Stokell will work with the Children’s Organ Transplant Association (COTA), a 501(c)3 not-for-profit organization that receives donations to assist with transplant-related expenses. The goal for the COTA campaign in honor of Stokell is $75,000.
With the cost of a transplant often exceeding $500,000, many transplant families are unable to shoulder the financial burden of such a procedure. The organization’s priority is to ensure that a transplant does not financially devastate a family. One hundred percent of all funds raised are used for patients’ transplant-related expenses.
Anyone interested in making secure credit card donation can do so online through a website COTA has established: www.COTAforJoshuaS.com. Donations also may be mailed to the Children’s Organ Transplant Association, 2501 West COTA Drive, Bloomington, Indiana, 47403. Checks or money orders should be made payable to COTA, with “In Honor of Joshua S” written on the memo line of the check. Fundraising proceeds will benefit COTA in honor of Stokell to assist with transplant-related expenses.
“My hope is that I can spread the word about my need for a transplant and the financial needs I have associated with it,” Stokell said. “My transplant pulmonologist is guessing that I won’t need a transplant for six months. However, because of the unpredictable nature of this disease at such a late-stage, that time could be quickly reduced or hopefully, extended.”
Team Creates Solar-Responsive Design Material for National Contest
A team of six UNC Charlotte students, led by chemistry faculty member Michael Walter and architecture faculty member Mona Azarbayjani, has created a solar-responsive design material that transforms windows into environmentally-responsive surfaces that can simultaneously provide shade and convert sunlight into usable electric energy.
They received honorable mention accolades with their design in the People, Prosperity, and Planet Student Design Competition for Sustainability held by the U.S. Environmental Protection Agency in Alexandria, Virginia, April 10-13.
In the fall of 2014, the UNC Charlotte team received a $15,000 grant to develop a project to address an environmental challenge found in the developed or developing world. They will present their proposal to compete for a P3 Award for grant funding up to $75,000 to further the project design, implement it in the field, and move it to the marketplace. A mixture of undergraduate and graduate students, the UNC Charlotte team includes two students from the Department of Chemistry and one student from the Department of Physics and Optical Science in the College of Liberal Arts & Sciences and three students from the School of Architecture in the College of Arts + Architecture.
With their project design, the unique nature of the material reacts to the intensity of the sunlight striking the window. Excess solar energy is then converted to electricity instead of heating the interior of a building. This material can be incorporated as a very thin layer on a glass surface, which can be used in different parts of the building’s exterior, such as skylights, façades, windows, or curtain walls.
“The purpose of this project is to lower the energy consumption of the building and to have it become more sustainable,” Walter said. “The buildings in the United States are one of the biggest areas where energy is wasted. They contribute so much to the increase in CO2. Think about the energy needed for lighting, heating and cooling.”
The project could revolutionize the use of glass in homes, buildings, and even automobiles. Here’s how it works: Micro-sized, wire-shaped solar cells are embedded in a thin film of clear, heat responsive plastic material. The film can be put on the surface of an existing window, or between panes when windows are manufactured. The plastic absorbs the heat that the sunlight produces and reacts by expanding, which causes the nearly invisible wires to bend, and in turn causes the window to become tinted. This allows the solar cells to absorb more visible light, increasing the efficiency of the window as a solar panel, which can help feed the building’s energy needs. Once the window cools, the plastic and the wires will return to their original positions
In October, the UNC Charlotte team received a commendation from Governor Pat McCrory. “I would like to congratulate UNC Charlotte on being awarded this grant,” McCrory said. “Innovation and cutting edge projects like these are the best of what North Carolina is about and will undoubtedly impact our environment and future in a positive way.”
In addition to the initial grant from the EPA, the project has been funded by university grants from the Energy Production and Infrastructure Center (EPIC), the Department of Chemistry, and the School of Architecture.
“I feel very lucky to be a part of this effort and in energy research,” said undergraduate physics major Jennifer Kassel, who is part of the Walter Research Group. “Knowing that my time and effort is contributing to the field of sustainability, something I am proud to be a part of, is very fulfilling. I love the projects I get to work on and getting to explain them to anybody who will listen. Also, getting to work with a professor who is very passionate about his work and other students who feel the same makes for a great environment.”
This is not the first time an interdisciplinary team of UNC Charlotte students has conducted research and design in solar energy and sustainability practices for a national competition. Led by Azarbayjani, a group of more than 40 students competed in the 2013 Solar Decathlon, sponsored by the US Department of Energy.
“One of the core objectives of the Solar Decathlon was to turn ideas into research,” Azarbayjani said. “Throughout the competition, we wanted to embrace all aspects of sustainability and the built environment. That’s where the idea of a responsive building envelop was born. This idea then served as a vehicle for our exploration in the P3 competition.”
Since 2004, the P3 Program has provided funding to student teams in all 50 states and Puerto Rico, committing over $10 million to cutting-edge, sustainable projects designed by university students. Nationally the grants were awarded to 42 teams of college and university students this year. Other North Carolina schools receiving the grant include Appalachian State University and North Carolina A&T State University.
Image: Students presenting at competition
Mathematical Finance Program Ranked in Top 25 Nationally
UNC Charlotte’s Master of Science in Mathematical Finance program in late 2014 was ranked No. 25 in the country by Financial Engineer.
This is the first national ranking for the Mathematical Finance program, which currently enrolls more than 100 students. The 2015 rankings are calculated based on a series of factors, including average GRE scores, starting salaries and bonuses, undergraduate GPA, acceptance rates and the number of employed graduates.
UNC Charlotte’s Mathematical Finance program is a joint program of the Department of Mathematics and Statistics in the College of Liberal Arts & Sciences and the Departments of Finance and Economics in the Belk College of Business. The city of Charlotte is the second-largest financial center in the United States.
The Master of Science in Mathematical Finance program at UNC Charlotte is designed to prepare students to pursue careers in finance. Increasingly firms of all types, but especially financial institutions, investment banks, commercial banks, insurance companies, investment funds, commodity firms, regulatory agencies and rating agencies, among many others, rely upon highly sophisticated finance models and tools to identify, measure, manage and hedge risk. The advent of these models has triggered the emergence of a new discipline, Mathematical Finance. This new discipline, sometimes also referred to as “financial engineering,” “computational finance,” or “quantitative finance,” requires professionals with extensive skills in both finance and mathematics.
The Mathematical Finance program draws upon faculty from three departments within UNC Charlotte: the Department of Finance from the Belk College of Business, the Department of Economics from the Belk College of Business, and the Department of Mathematics and Statistics from the College of Liberal Arts & Sciences. In addition, faculty members from the College of Computing and Informatics and the Department of Business Information Systems & Operations Management in the Belk College of Business are involved in teaching several concentration courses. The program also invites highly experienced executives from the Charlotte-area to teach several concentration courses.
Financial Engineer publishes rankings for financial engineering, financial mathematics, quantitative finance, computational finance and mathematical finance graduate programs in the United States.